Gaia Scilironi

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

The adenylate cyclase toxin (CyaA) from Bordetella pertussis intoxicates host cells by directly translocating its N-terminal catalytic domain across the plasma membrane; however, the forces driving this unique process remain poorly defined. Here, we dissect the membrane transloca...