Gabriela Mirecka

DAPEG, a Modular Peptidomimetic Concept for Intracellular Delivery: Architecture, Trajectory, and Outlook in the Context of Peptidomimetic Transfection Reagents

Abstract Cell-penetrating peptides (CPPs) remain a leading nonviral strategy for the intracellular delivery of polynucleotides and folded proteins, but native α-peptide CPPs are constrained by proteolysis, dose-dependent cytotoxicity, and endosomal entrapment. Peptidomimetic rede...