Frédéric Lamoliatte

USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage

Abstract Proteolytic processing is a fundamental regulatory mechanism in eukaryotic cells, yet the molecular identities and mechanisms underlying such events are often poorly defined. Silencing Defective 2 (SDE2), an essential human protein, plays important roles in mRNA splicing...