Frank R Fronczek

Synthetic Studies toward Anguidine: Assembly of the Tricyclic Ether Scaffold

Anguidine, a type A trichothecene (TCN) isolated from Fusarium graminearum, features a highly functionalized 6/6/5 tricyclic scaffold incorporating a central six-membered ether ring and a C12–C13 epoxide. Its pronounced bioactivity and structural complexity render it a challengin...