Francis H.C. Tsao

Secretory Phospholipase A2–Albumin–Membrane Interactions: A Proposed Mechanism of Internal Cell and Tissue Injury in Systemic Inflammation

Systemic inflammation in sepsis causes internal cell and tissue injury through mechanisms that remain incompletely understood. Secretory phospholipase A2 (sPLA2-IIA; hereafter, sPLA2), a potent inflammatory mediator whose circulating levels rise dramatically during sepsis, hydrol...