Francesco Merlino

A Thiophilic Metal-Mediated Cysteine S -Detritylation Strategy: Enhancing Orthogonality in Solid-Phase Peptide Synthesis

Abstract The selective manipulation of cysteine residues in solid-phase peptide synthesis (SPPS), beyond disulfide bridge formation, remains challenging, and an efficient protocol for the selective removal of the widely used trityl (Trt) protecting group under solid-phase conditi...