Francesco Izzo

Systems serology identifies differential pan-viral seroreactivity profiles associated with healthy aging and cancer

Abstract A viral exposure signature (VES) has previously been shown to predict the development of hepatocellular carcinoma (HCC) in at-risk individuals through comprehensive serological profiling using the VirScan platform. Whether cumulative antimicrobial immune histories are as...

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability

PIK3CA, which encodes the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), is one of the most frequently altered oncogenes in human cancer and a major driver of tumor initiation, progression, metastasis, and therapeutic resistance. Over the past two decades, advances...