Francesca Rizzo

Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function

ABSTRACT Cellular function relies on tightly regulated mitochondrial proteolysis, which controls organelle protein quality and specific mitochondrial functions, including gene expression and oxidative phosphorylation. In human mitochondria, one of the main proteolytic machineries...

Step-brothers in arms, SAGA and ATAC co-activator complexes, use different strategies

Abstract Transcriptional co-activator complexes play essential roles in regulating gene transcription by integrating signals from transcription factors and chromatin. Among these, the SAGA (Spt-Ada-Gcn5 acetyltransferase) and ATAC (Ada Two-A Containing) complexes represent relate...