Franca Fagioli

3D virtual reconstruction: usefulness in preoperative planning for oncologic renal surgery in children

Preoperative planning for complex pediatric renal masses can be challenging, especially when nephron-sparing surgery (NSS) is recommended. We report our experience using 3D virtual reconstruction (3DVR) and its impact on surgical decision making. Patients with complex renal masse...

The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma

Abstract Background Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Eluci...