for the Alzheimer’s Disease Neuroimaging Initiative

Brain signatures of body mass index predict cardiometabolic and respiratory disease status

Abstract Despite advances in brain biomarkers using neural networks, the effects of body mass on brain structure have been neglected, particularly in connection with noncommunicable diseases. Here, we isolated brain biomarkers of body mass index (BMI) and evaluated their associat...

From Biomarker Anchors to Disease-State Transitions: A Biologically Anchored Probabilistic Principal Component Analysis Framework for Alzheimer’s Disease Progression Modeling

To develop and validate a biomarker-anchored probabilistic principal component analysis (PPCA) framework for identifying biologically interpretable latent dimensions of Alzheimer’s disease (AD) and evaluating their utility for disease progression modeling. Data from 1058 particip...