Fernando Mendizábal

Unraveling theMolecular Basis of NSD3 AllostericActivation Driven by Nucleosome Binding: A Multiscale MD and QM/MMApproach

Abstract Nuclear receptor-binding SET domain 3 (NSD3) is a methyltransferase responsible for mono- and di-methylation of histone H3 lysine 36, whose hyperactivation is linked to accelerated cancer cell proliferation. Isolated NSD3 is autoinhibited due to a conformation that preve...