Feng Ni

A Novel Synthesis of 5-HT4 Receptor Intestinal-Restrictive Bivalent Agonist: SIPI11588

SIPI11588 is a 5-HT4 receptor agonist with potential bioactivity that significantly enhances whole-gut and colonic transit and defecation. The original linear synthetic route, starting from 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid (3), involving seven steps (37.91...