Feng Lu

Repurposing irosustat for malaria: host-targeted antiplasmodial activity via cholesterol sulfate modulation against drug-resistant Plasmodium falciparum

Abstract Background The urgent global need for novel antimalarial drugs targeting Plasmodium falciparum has intensified due to rising mortality and drug resistance. This study examines a host-directed strategy targeting lipid metabolism by evaluating the antiplasmodial activity o...