Felix Wojcik

Immobilized Thiol Catalysts for Native Chemical Ligation in Flow

Abstract Native chemical ligation (NCL) is a well-established research tool used to access long and complex peptides that cannot be efficiently synthesized by other means such as linear solid-phase peptide synthesis (SPPS). However, its broader application beyond the research lab...

Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation

Abstract Late-stage functionalization (LSF) of peptides offers direct access to structurally diverse analogues, but developing general, chemoselective protocols remains challenging due to the complexity of peptide substrates and the vast number of reaction variables. Traditional...