Felix Mahfoud

Improving heart failure care in rural Africa: overcoming implementation barriers

Abstract In this narrative review, we present the most important heart diseases causing heart failure in sub-Saharan Africa, discuss challenges, uncertainties and research gaps, and suggest strategies to lower the burden of disease. Hypertensive heart disease is the most common c...

Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting

Background Diagnosing myocardial infarction in patients with prior coronary artery bypass grafting (CABG) remains challenging, primarily because of lower diagnostic accuracy of high‐sensitivity cardiac troponin (hs‐cTn). cMyC (cardiac myosin‐binding protein C), because of its fas...

High-density mapping of his-ventricular intervals: impact of recording site and sex-specific differences

Abstract Background Accurate assessment of the His–ventricular (HV) interval is essential to diagnosing infranodal conduction disease, but the influence of recording site and sex on HV values is not well defined. Objective To evaluate the impact of measurement location and sex on...

Left atrial anatomy and atrial arrhythmia recurrence after pulsed-field ablation

Abstract Background The impact of left atrial (LA) anatomical features on atrial arrhythmia (AA) recurrence after pulsed-field (PF)-based pulmonary vein isolation (PVI) is unknown. This study aimed to assess LA anatomical features associated with long-term AA recurrence after PVI...

Training and validation of a 12-lead ECG-based deep-learning model for myocardial infarction subtypes

Abstract A convolutional neural network was developed to detect acute myocardial infarction (AMI) subtypes from digital 12-lead ECGs. Trained on 173,396 hospitalized patients’ ECGs, the model underwent fine-tuning and internal validation in 7591 patients and external validation i...