Felipe Heemann

Synthetic cannabinoids and the purinergic–dopaminergic axis: P2X7 as a primary sensor of neuroinflammatory injury and the role of adenosine receptor heteromers in emerging NPS toxicity

Synthetic cannabinoids (SCs), marketed as Spice, K2, and dozens of successor compounds, constitute one of the most pharmacologically dangerous categories of new psychoactive substances (NPS) currently in circulation. Their extreme toxicity relative to Δ9-tetrahydrocannabinol (THC...

Synthetic cannabinoids and the purinergic–dopaminergic axis: P2X7 as a primary sensor of neuroinflammatory injury and the role of adenosine receptor heteromers in emerging NPS toxicity

Synthetic cannabinoids (SCs), marketed as Spice, K2, and dozens of successor compounds, constitute one of the most pharmacologically dangerous categories of new psychoactive substances (NPS) currently in circulation. Their extreme toxicity relative to Δ9-tetrahydrocannabinol (THC...

Conative hormophoria: A dynamical-regime hypothesis for intra-spectrum differentiation in autism

The 2013 removal of Asperger’s syndrome from DSM-5 was defended on evidential grounds that were, at the level of measurement, sound: inter-rater reliability for the distinction was poor, and symptom distributions across the autism spectrum are continuous. From these findings the...

Conative hormophoria: A dynamical-regime hypothesis for intra-spectrum differentiation in autism

The 2013 removal of Asperger’s syndrome from DSM-5 was defended on evidential grounds that were, at the level of measurement, sound: inter-rater reliability for the distinction was poor, and symptom distributions across the autism spectrum are continuous. From these findings the...

Dimensional open-ended evolution (OEE) as a hybrid dynamical phenomenon

Classical evolutionary theory, confined to fixed-dimensional state spaces and static parameters, cannot model meta-evolution: the phenomenon in which the rules governing heredity, mutation, and selection are themselves transformed by the population they govern. We formalize self-...

Conative hormophoria: A dynamical-regime hypothesis for intra-spectrum differentiation in autism

Background: The 2013 removal of Asperger’s syndrome from DSM-5 was defended on evidential grounds that were, at the level of measurement, sound: inter-rater reliability for the distinction was poor, and symptom distributions across the autism spectrum are continuous. From these f...

Conative hormophoria: A dynamical-regime hypothesis for intra-spectrum differentiation in autism

Background: The 2013 removal of Asperger’s syndrome from DSM-5 was defended on evidential grounds that were, at the level of measurement, sound: inter-rater reliability for the distinction was poor, and symptom distributions across the autism spectrum are continuous. From these f...