Federico Roncaroli

Apc-deficient pituitary stem cells drive adamantinomatous craniopharyngioma through senescence-associated inflammation

Abstract Adamantinomatous craniopharyngiomas (aCPs) are complex intracranial neoplasms that arise in the sellar and suprasellar region of the brain, affecting the endocrine and nervous systems, causing severe sequelae. Although most of aCPs are driven by somatic mutations in β-ca...