Federico Pandolfi

MolecularStriptease of a Thiadiazolopyrimidine HitYields a Streamlined, Artifact-Free NADPH Mimic for NOX Inhibition

Abstract The convergence of oxidative stress and inflammation drives neurodegeneration and cancer, positioning NADPH oxidases (NOXs) as critical therapeutic targets. Starting from the polyfunctional thiadiazolopyrimidine hit 1, we systematically truncated its peripheral arms to m...