Farshad Heydari

Engineering CAR-NK cell platforms for breast cancer: metastatic interception, perioperative control, and emerging platelet-guided biomimetic strategies

Breast cancer metastasis remains the leading cause of disease-related mortality, highlighting the need for strategies that can intercept circulating tumor cells, suppress micrometastatic outgrowth, and eliminate residual disease during the perioperative window. Although CAR-T cel...

Platelet–neutrophil cooperation in premetastatic niche formation: from NETosis and stromal conditioning to nanotherapeutic interception

Metastasis remains the leading cause of cancer-related mortality, yet the metastatic cascade is initiated long before circulating tumor cells reach distant organs. Central to this early phase is the premetastatic niche (PMN), a dynamic and tumor-conditioned microenvironment in wh...