Faranak Kargar

Engineering CAR-NK cell platforms for breast cancer: metastatic interception, perioperative control, and emerging platelet-guided biomimetic strategies

Breast cancer metastasis remains the leading cause of disease-related mortality, highlighting the need for strategies that can intercept circulating tumor cells, suppress micrometastatic outgrowth, and eliminate residual disease during the perioperative window. Although CAR-T cel...

Platelet–NK cell interplay in advanced coronary artery disease is associated with pre-exhausted NK cell dysfunction without upregulation of the immune checkpoint receptor NKG2A

Platelet crosstalk with leukocytes plays a key role in the development of atherosclerosis. However, different immune cells are involved in the disease’s pathology, with Tregs showing protective effects against atherosclerosis, whereas NK cells appear to contribute to both atherog...