Fanrong Zhao

Multi-omics profiling coupled with SHAP analysis and molecular dynamics simulation identifies PIM1 as a therapeutic target in PET-MPs-associated gastric cancer

This study aimed to explore the molecular mechanisms underlying gastric cancer (GC) progression driven by polyethylene terephthalate microplastics (PET-MPs), and screen potential prognostic biomarkers for this specific type of GC. We established an integrated research pipeline co...

Ultrasound-Assisted Sustainable Extraction of Berberine from Coptis chinensis Franch. Using Temperature-Responsive Deep Eutectic Solvents

Abstract The development of deep eutectic solvents (DESs) that can be readily and sustainably recycled is expected to reduce costs and enhance the environmental friendliness of extracting plant-derived active ingredients. Here, a novel temperature-responsive DES prepared from pro...

Behavioral Effects and Potential Mechanisms of Imidacloprid-and Flupyradifurone-Induced Neurotoxicity in Caenorhabditis elegans

Abstract Neonicotinoid insecticides raise concerns about neurotoxicity in nontarget organisms, motivating evaluation of alternatives such as flupyradifurone (FPF). We compared the neurotoxicity of imidacloprid (IMI) and FPF in Caenorhabditis elegans after 72 h exposure to 0.1–100...