Fangyuan Zheng

Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer’s Disease

Abstract Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) to regulate microglia-mediated neuroinflammation represents a promising therapeutic strategy for Alzheimer’s disease (AD). To address the limited brain penetration of our earlier lead ZJCK-6...

Hyperopic reserve depletion and myopia burden among primary school students in Xingtai, China, 2 years post-covid-19: a cross-sectional study with refraction validation

Myopia has become a global public health crisis with an annual economic burden of up to $202 billion. Hyperopic reserve (HR) plays a pivotal role in myopia prevention, as excessive near-work in children depletes physiological HR, accelerates emmetropization, and leads to early my...