Fang Zhou Yin

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

ABSTRACT Toosendanin (TSN) is a highly potent natural anticancer compound derived from the fruit of Fructus Meliae Toosendan. In this study, TSN inhibited melanoma cell proliferation and cell‐cycle progression, induced apoptosis, and suppressed metastasis in both in vitro and in...