Fang Ye

Multi-omics reveals evolution from CD7-negative T cell dysregulation to EBV-positive LPD after CD7 CAR-T therapy

EBV activation specifically occurs in a subset of patients following CD7 CAR-T therapy, subsequently leading to EBV-positive lymphoproliferative disorder (EBV+ LPD), descriptively referred to as post-CD7 CAR-T lymphoproliferative disorder (PCLD) in this study. To comprehensively...

Large-scale proteomic characterization reveals clinically relevant subtypes of early-stage papillary thyroid cancer for prognostic prediction

Papillary thyroid cancer (PTC) has a rising incidence. The majority are diagnosed at an early stage, albeit with a minority exhibiting aggressive tendencies. Given its generally indolent nature, controversy persists regarding the management of early-stage PTCs, particularly surgi...