Fan Li

MMP-9–responsive stealth-to-activation liposomes enable tumor-selective PD-L1 degradation via dual-PEG shedding

Abstract PD-1/PD-L1 blockade benefits patients across > 20 cancer types, yet durable responses remain limited and antibody therapies only transiently engage the axis while causing systemic immune-related adverse events. We report lipoRDPA, a rationally designed liposomal degrader...

The Water-Sediment Regulation Scheme Drives Phytoplankton Dynamics in the Yellow River Estuary

The Water-Sediment Regulation Scheme (WSRS) of the Yellow River is a large-scale anthropogenic intervention designed to alleviate downstream channel siltation, yet its long-term ecological effects on estuarine phytoplankton communities remain contentious. Based on a 12-year (2011...