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HOT1 functions as a homodimer to promote ALT-permissive chromatin

Telomere homeostasis is a tightly regulated and dynamic process sustained by a network of proteins that organize telomeric chromatin and safeguard chromosome stability. In ALT-positive cells, telomere maintenance relies on recombination-based mechanisms and is modulated by local...

Identification and binding-site mapping of RNA-binding proteins interacting with microRNA precursors in Arabidopsis

Abstract Background MicroRNAs (miRNAs) play key roles in modulating gene expression. Upon transcription, primary miRNA transcripts (pri-miRNAs or MIRNAs ) fold into stem-loop structures. Endonucleolytic cleavage releases a miRNA/miRNA* duplex from the stem, which is subsequently...

DVE-1 is a telomere-binding protein and links the NuRD complex to telomere regulation in C. elegans

Telomeres are repetitive DNA sequences at the ends of linear chromosomes bound by specialized proteins. In our previous quantitative proteomics screen for telomere-binding proteins of Caenorhabditis elegans , we identified DVE-1, a homolog of mammalian SATB proteins and a transcr...