Fabrizio Merciai

Sub-3 μm porous graphitic carbon for highly polar metabolomics: orthogonal selectivity and comparison with HILIC and reversed-phase chromatography

Abstract The analysis of the polar metabolome remains a major challenge in LC–MS. Beyond established hydrophilic interaction liquid chromatography (HILIC) and reversed-phase (RP) workflows, alternative and orthogonal chromatographic approaches are required to improve the detectio...