Fabian M. Kulier

Dual‐Function Cosubstrates Enable Threonine Dehydrogenase‐Driven Chemoenzymatic Pyrrole Synthesis

ABSTRACT Preparative biocatalytic synthesis of substituted pyrroles remains challenging despite recent advances in enzymatic α‐aminoketone generation. In this study, we report a concurrent chemoenzymatic cascade to disubstituted pyrroles based on threonine dehydrogenase (ThrDH)‐c...

Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations

Reductive amination catalysed by imine reductases and reductive aminases has emerged as a powerful method for the asymmetric synthesis of chiral amines, yet the generality and practical limitations of these enzymes remain poorly understood. Here, we combine large-scale, iterative...