F. Xavier Gomis‐Rüth

Structure of astacin and the discovery of metzincins

Abstract The X-ray crystal structure of astacin from the freshwater crayfish Astacus astacus published in 1992 was the second structural prototype of a zinc metalloendopeptidase solved after thermolysin from Bacillus thermoproteolyticus 20 years earlier. Astacin became the foundi...