Eun-Hee Ha

Development and Preclinical Evaluation of Novel STK3/4 Inhibitors with Anti-Obesity Potential

Background: Obesity is associated with impaired adipocyte metabolism driven in part by mitochondrial dysfunction.Serine/ threonine-protein kinase 3 (STK3) and STK4 promote mitophagy, leading to reduced mitochondrial mass in adipose tissue.Thus, inhibition of STK3/4 represents a p...