Eric Lazartigues

ACE2 downregulation contributes to adverse cardiovascular and reproductive outcomes in female mice on high fat diet

Obesity is a growing concern among women of reproductive age, as it can significantly impact both maternal and fetal health. A potential mechanism linking obesity to cardiometabolic dysfunction is the imbalance between the classical (pressor) and the compensatory (protective) arm...

A Vagal–Renal–Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury

Background: Acute kidney injury (AKI) is associated with maladaptive increases in renal sympathetic nerve activity (RSNA) and frequently progresses to chronic kidney disease. Neuromodulatory strategies that suppress sympathetic outflow may provide therapeutic benefit. We tested w...