Eric A. Franzosa

Using the housekeeping gene cpn60 as a marker for microbial community profiling and viability assessment

Abstract High-throughput sequencing has revolutionized microbiome research, yet distinguishing viable from nonviable microbes in complex communities remains challenging. Microbial viability underlines microbiome function, which is mostly driven by living, active members. Transcri...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...