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Recent research
- Health & MedicineOpen access
A Novel Chemotype of Orally Active SARS-CoV-2 NSP14 Methyltransferase Inhibitors
Abstract The periodic emergence of human coronaviruses (hCoVs) necessitates direct-acting antivirals targeting underexploited viral proteins with broad-spectrum potential. Building on our discovery of TDI-015051, a first-in-class SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (...