Enrico Glaab

Causal analysis of Alzheimer’s disease molecular data

Abstract Background Genome-wide studies have revealed many molecular associations with Alzheimer’s disease (AD), but association alone does not identify cause, mechanism, or treatable target. This review surveys methods used to infer causal relationships from AD molecular data an...

Screening Luxembourg's older general population for probable REM sleep behaviour disorder with a nationwide online survey

Abstract REM Sleep Behaviour Disorder (RBD) is a hallmark of the prodromal phase of α-synucleinopathies. We aimed to describe the prevalence of probable RBD and to assess its associations with demographics, cognition, and location in a large sample of older adults in Luxembourg,...

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

BACKGROUND: The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. OBJECTIVE: To perform an integrative multi-omics reanalysis of single-cell transcriptomic and epigenomic data to identify convergent alte...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

LRRK2-G2019S impairs astrocyte differentiation and triggers a senescence-like phenotype in Parkinson’s disease models

Abstract Astrocytes are increasingly recognised as essential contributors to both physiological brain function and neurodegenerative diseases. Here, we describe how the Parkinson’s disease (PD)-associated mutation LRRK2-G2019S affects astrocytes using autoptic brain samples and P...