Enrico Borrelli

Clinical exit strategy in anti-VEGF therapy for neovascular AMD: incidence of recurrence and risk factors for relapse

PURPOSE: To evaluate the recurrence rate of neovascular activity after discontinuation of intravitreal anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular age-related macular degeneration (AMD) and to identify baseline clinical and imaging factors...

Deep learning–based prediction of one-year functional and structural outcomes in treatment-naïve DMO after anti-VEGF therapy

Abstract Purpose To evaluate whether baseline structural optical coherence tomography (OCT) scans contain prognostic information that can be used by deep learning models to predict one-year functional and anatomical outcomes in treatment-naïve diabetic macular oedema (DMO). Desig...

OphthoEvidence Report: Comparative effects of treatments for geographic atrophy secondary to age-related macular degeneration: A protocol for a living systematic review and network meta-analysis

Background Geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), leads to legal blindness in approximately 16% of affected individuals within 6 years. Numerous trials have evaluated interventions to slow GA progression, and many studies are ongoing....

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Aflibercept 8 mg for diabetic macular edema and neovascular age-related macular degeneration: an italian expert consensus paper

To provide consensus recommendations on the clinical use of aflibercept 8 mg in managing neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the real-world setting. A modified Delphi study was undertaken, involving ophthalmologists from special...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

Real-world comparative effectiveness of faricimab versus aflibercept 2 mg in treatment-naïve exudative neovascular AMD patients treated with a treat-and-extend regimen

Abstract Purpose To compare the real-world effectiveness of faricimab versus aflibercept 2 mg in treatment-naïve patients with neovascular age-related macular degeneration (nAMD). Methods We analysed treatment-naïve nAMD patients aged ≥50 years initiating intravitreal anti-VEGF t...