Enrica Migliaccio

A scalable Zebrafish Platform for genetic validation and functional discovery of stage-specific breast cancer metastasis regulators

Metastatic disease accounts for over 90% of breast cancer-related deaths, yet scalable in vivo models for functional analysis of distinct metastatic steps remain limited. Here we show that an optimized zebrafish xenotransplantation platform enables quantitative, stage-resolved an...

Mapping the NFYA 3′UTR landscape identifies alternative polyadenylation as a targetable vulnerability in prostate cancer

Abstract Background Alternative polyadenylation (APA) is increasingly recognized as a pervasive oncogenic mechanism that reshapes post-transcriptional gene regulation and promotes tumor aggressiveness. Whether APA contributes to the dysregulation of NFYA —encoding the regulatory...