En-Shuo Liu

A multimodal deep learning method based on multiple medical images for Fuchs endothelial corneal dystrophy diagnosis

To establish a multimodal deep learning network for the automated diagnosis of Fuchs endothelial corneal dystrophy (FECD). The ResNet-50 neural network was trained and validated using patients with FECD, patients with other corneal endothelial disorders, and healthy controls. At...

Autologous hinge-masked anti-TNFα antibody to mitigate immunogenicity, antigen sink effects, and anti-idiotypic antibody interference

Abstract Background Monoclonal antibody (mAb) therapies are limited by factors affecting their pharmacokinetics (PK), such as anti-idiotypic antibodies (anti-ID Abs) and the antigen sink effect. To address this, we developed six pro-anti-TNFα Abs (pro-Infliximab) incorporating un...