Ellison Ober

Transgene expression kinetics and replication potential of recombinant adenovirus serotype 4 in a mouse model and its use as a herpes simplex virus vaccine

Human adenovirus serotype 4 (Ad4) is used as a replication-competent oral vaccine that safely and effectively prevents Ad4 respiratory illness in US military personnel. Recombinant Ad4 vaccine candidates elicit mucosal and systemic immune responses against respiratory viruses in...