Elise Koch

A GENOME WIDE ASSOCIATION ANALYSIS ON NITRENIUM-DERIVED CLOZAPINE METABOLITES – A STUDY WITH 306 SUBJECTS WITH KNOWN SMOKING STATUS

Background and aim Clozapine is the most effective antipsychotic for treatment of schizophrenia, yet its clinical use is limited by potentially life-threatening side effects including agranulocytosis and myocarditis. It has been suggested that bioactivation of clozapine to its re...

A GENETIC APPROACH TO UNDERSTANDING PSYCHOTROPIC DRUG EFFECTS ON BRAIN STRUCTURE

While neuroimaging studies have reported many brain alterations linked to psychiatric disorders, there has been substantial heterogeneity in findings. Effects of psychotropic medications on brain structure likely contribute to this inconsistency, yet disentangling disorder from d...

GENOME-WIDE ASSOCIATION STUDIES OF NON-RESPONSE TO ANTIDEPRESSANTS LEVERAGING HARMONIZED POPULATION-WIDE REAL-WORLD DATA FROM HEALTH REGISTRIES AND BIOBANKS

While recent genome-wide association studies (GWAS) have shown that antidepressant response has a genetic component, the robust identification of genetic associations in current studies is limited by insufficient sample sizes as well as variability in defining treatment-related p...