Elisavet Kosma

The TET Protein Family in Gliomas: Epigenetic Regulation, Molecular Pathogenesis, and Therapeutic Opportunities

Epigenetic dysregulation is a defining feature of glioma pathogenesis, with aberrant DNA methylation contributing to tumor initiation, cellular plasticity, progression, and therapeutic resistance. The ten-eleven translocation (TET) family of dioxygenases (TET1, TET2, and TET3) ca...

Targeting SUV4–20H2-mediated H4K20 methylation restrains growth and migration in pediatric high-grade astrocytomas

Pediatric astrocytomas are characterized by increased molecular and clinical heterogeneity with epigenetic alterations contributing to aggressiveness and therapy resistance. The repressive histone mark H4K20 trimethylation (H4K20me3) and the methyltransferase SUV4–20H2 (KMT5C) ar...