Elena Hogea

Olorofim for Invasive Fungal Diseases in Patients with Limited or No Treatment Options: A Systematic Review

Olorofim, the first orotomide antifungal, is active against Aspergillus spp., Lomentospora prolificans, Scedosporium spp. and Coccidioides spp. We reviewed published clinical reports of olorofim in invasive fungal disease (IFD) with limited or no treatment options. PubMed/MEDLINE...

Salivary Inflammatory Mediators and a Tongue-Coating Dysbiosis Index as Mechanistic Correlates of Adjunctive Halitosis Therapy: A Randomized Pragmatic Trial

Background: Intra-oral halitosis is sustained by tongue-coating biofilm, but ecological and host inflammatory responses to adjunctive therapy remain unclear. Methods: In a 4-week randomized pragmatic trial (117 adults; 39 per arm; ClinicalTrials.gov NCT05876321), we compared stan...