Edward R. Kost

ERX 208 induces endoplasmic reticulum stress and suppresses DNA damage repair to enhance chemotherapy sensitivity

Abstract Ovarian cancer (OCa) remains the most lethal gynecologic malignancy, driven in part by intrinsic and acquired therapeutic resistance to DNA damaging chemotherapies. We previously identified that ERX-208 targets the protein encoded by Lysosomal acid lipase (LIPA) to induc...

Multidisciplinary management of adult-type ovarian granulosa cell tumor in a patient with severe peripheral arterial disease and chronic limb-threatening ischemia: a case report

Reports describing the concurrent management of adult-type granulosa cell tumor (AGCT) and chronic limb-threatening ischemia (CLTI) are exceedingly rare, highlighting the challenges of treating a rare gynecologic malignancy in a medically fragile patient with severe peripheral ar...