Edward M. De Robertis

Downstream of β-catenin: A positive feedback loop between Goosecoid and Nodals in Spemann’s organizer

We report on the role of the homeobox gene goosecoid ( gsc ) within an epistatic pathway that mediates body axis formation in Xenopus . Embryos depleted of β-catenin form exclusively ventral structures and lack all traces of axial structures. Microinjection of gsc mRNA rescues an...