Eduarda G. R. Fernandes

The challenges of direct Claisen–Schmidt condensation in the synthesis of polyhydroxylated bischalcones: experimental results supported by DFT calculations

The synthesis of chalcones commonly relies on the Claisen–Schmidt condensation, an attractive reaction owing to its operational simplicity and favorable atom economy. However, its application to acetophenones bearing multiple hydroxy substituents can be problematic, often requiri...

Evaluation of Passiflora edulis Seed Extract and Piceatannol in Attenuating Hyperglycemia and Oxidative Stress Using Human and Nonhuman Antidiabetic Enzymes, Human Neutrophil Oxidative Burst, and Embryonic Zebrafish Hyperglycemia Model

Abstract Passiflora edulis seeds are frequently discarded as agro-industrial residues despite being a source of bioactive compounds such as piceatannol (PIC). Their valorization through ethanolic extraction aligns with circular economy principles and enables the investigation of...