Duncan R. Smith

Systematic interactome analysis identifies OCRL as a DENV 2 NS4A interactor that inhibits viral replication through a mechanism independent of global actin cytoskeleton rearrangement

Dengue virus (DENV) is a medically important human pathogen belonging to the genus Orthoflavivirus . DENV encodes seven non-structural (NS) proteins which exert multiple cellular effects. NS4A is a 16 kDa membrane-associated protein; however, its functions in orthoflavivirus infe...