Drew R. Jones

Highly multiplexed mammalian metabolic engineering with a shotgun approach

Mammalian metabolic engineering advances basic biology, bioproduction and cell therapy. However, as pathway complexity increases, so does the size of the combinatorial design space and required DNA constructs, rendering unbiased screens intractable. Here, we developed shotgun gen...

Secreted filarial acetylcholine analogs modulate parasite reproduction and host physiology

Abstract Lymphatic filariasis, caused by Brugia malayi , leads to chronic lymphatic dysfunction and lymphedema. The molecular mechanisms underlying interactions between filarial worms and their hosts remain poorly understood. Using untargeted metabolomics, we identify previously...