Dr Stuart Smith

45 Predicting sites of tumour progression in the invasive margin of glioblastomas (PRaM-GBM Study): a multicentre imaging study

Abstract Introduction Despite advances in surgery and radiotherapy, glioblastoma patients often experience progression within a year, adjacent to the resection cavity. Conventional imaging techniques are not sensitive enough to detect invasive tumour, leaving occult tumour undete...

165 Astrocyte–Glioblastoma Metabolic Interactions at the Invasive Margin Reveal Therapeutic Vulnerabilities

Abstract Introduction Glioblastoma is an aggressive brain tumour that, despite multimodal treatment, almost always recurs. Infiltrative tumour cells within the brain microenvironment are thought to drive recurrence and are supported by surrounding non-cancerous brain cells. Among...