Douglas A. Lauffenburger

Systems biology framework for the rational design of operational conditions for in vitro/in vivo translation of tissue models

Preclinical models are used extensively to study diseases and therapies. In vitro monoculture or microphysiological system (MPS) platforms incorporating multiple different human cell types can emulate diseased tissues, but determining experimental conditions (e.g., media suppleme...

Maternal influenza vaccination boosts durable breast milk antibody-mediated protection in infants

Influenza contributes to significant disease burden worldwide, and young infants are at an increased risk of severe influenza infection. Maternal antibodies transferred across the placenta and through breast milk confer anti-influenza immunity to the newborn. Placental transfer p...