Dorota Tomaszewska-Zaremba

Inflammation induced by endotoxin from Escherichia coli enables the central action of caffeine on GnRH/LH secretion in female sheep

Caffeine is considered to be the most utilized psychoactive stimulant worldwide. It easily crosses the blood-brain barrier and may antagonize adenosine receptors and activate ryanodine receptors in the brain. Administered peripherally, caffeine reduces inflammatory-associated cha...