Dooil Jeoung

Extrachromosomal DNA: A New Therapeutic Frontier for Overcoming Cancer Drug Resistance

Extrachromosomal DNAs (ecDNAs) are acentric circular DNA molecules that frequently harbor amplified oncogenes and their regulatory elements. Although ecDNAs occur at low levels in normal cells, oncogenic ecDNAs are enriched in cancer, where they promote tumor evolution, intratumo...